Journal article

Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity

Roland Lang, Andrew L Gundlach, Fiona E Holmes, Sally A Hobson, David Wynick, Tomas Hoekfelt, Barbara Kofler

PHARMACOLOGICAL REVIEWS | AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS | Published : 2015

Abstract

Galanin was first identified 30 years ago as a "classic neuropeptide," with actions primarily as a modulator of neurotransmission in the brain and peripheral nervous system. Other structurally-related peptides-galanin-like peptide and alarin-with diverse biologic actions in brain and other tissues have since been identified, although, unlike galanin, their cognate receptors are currently unknown. Over the last two decades, in addition to many neuronal actions, a number of nonneuronal actions of galanin and other galanin family peptides have been described. These include actions associated with neural stem cells, nonneuronal cells in the brain such as glia, endocrine functions, effects on met..

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University of Melbourne Researchers

Grants

Awarded by NHMRC (Australia)


Awarded by European Union


Awarded by Austrian Research Promotion Agency


Awarded by Diabetes UK


Awarded by Medical Research Council


Funding Acknowledgements

Support to A.L.G. was provided by NHMRC (Australia) (Fellowship Grant 1005985), a NARSAD Independent Investigator Award, and the Victorian Government Operational Infrastructure Support Programme. Support to F.E.H., S.A.H., and D.W. was provided by the Medical Research Council, Wellcome Trust, and Diabetes UK. Support to T.H. was provided by The Marianne and Marcus Wallenberg Foundation, the Swedish Research Council, Funds from Karolinska Institutet, a NARSAD Distinguished Investigator Award, an unrestricted Bristol-Myers Squibb Neuroscience grant, and the 6th Framework Program of the European Union (NewMood, LSHM-CT-2004-503474). Support for this work was provided by a grant from the Austrian Research Promotion Agency (FFG, 822782/THERAPEP) to B.K.