Journal article

INCREASED GAMMA-AMINOBUTYRIC-ACID RECEPTOR FUNCTION IN THE CEREBRAL-CORTEX OF MYOCLONIC CALVES WITH AN HEREDITARY DEFICIT IN GLYCINE STRYCHNINE RECEPTORS

SCR LUMMIS, AL GUNDLACH, GAR JOHNSTON, PAW HARPER, PR DODD

JOURNAL OF NEUROCHEMISTRY | WILEY-BLACKWELL | Published : 1990

Abstract

Inherited congenital myoclonus (ICM) of Poll Hereford cattle is a neurological disease in which there are severe alterations in spinal cord glycine-mediated neurotransmission. There is a specific and marked decrease, or defect, in glycine receptors and a significant increase in neuronal (synaptosomal) glycine uptake. Here we have examined the characteristics of the cerebral gamma-aminobutyric acid (GABA) receptor complex, and demonstrate that the malfunction of the spinal cord inhibitory system is accompanied by a change in the major inhibitory system in the cerebral cortex. In synaptic membrane preparations from ICM calves, both high-and low-affinity binding sites for the GABA agonist [3H]m..

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