Journal article

A phospholipid kinase regulates actin organization and intercellular bridge formation during germline cytokinesis

JA Brill, GR Hime, M Scharer-Schuksz, MT Fuller

DEVELOPMENT | COMPANY OF BIOLOGISTS LTD | Published : 2000

Abstract

The endgame of cytokinesis can follow one of two pathways depending on developmental context: resolution into separate cells or formation of a stable intercellular bridge. Here we show that the four wheel drive (fwd) gene of Drosophila melanogaster is required for intercellular bridge formation during cytokinesis in male meiosis. In fwd mutant males, contractile rings form and constrict in dividing spermatocytes, but cleavage furrows are unstable and daughter cells fuse together, producing multinucleate spermatids. fwd is shown to encode a phosphatidylinositol 4-kinase (PI 4-kinase), a member of a family of proteins that perform the first step in the synthesis of the key regulatory membrane ..

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University of Melbourne Researchers