Journal article

Phenomenological Characterization of Memory Complaints in Preclinical and Prodromal Alzheimer's Disease

Rachel F Buckley, Kathryn A Ellis, David Ames, Christopher C Rowe, Nicola T Lautenschlager, Paul Maruff, Victor L Villemagne, S Lance Macaulay, Cassandra Szoeke, Ralph N Martins, Colin L Masters, Greg Savage, Stephanie R Rainey-Smith, Alan Rembach, Michael M Saling



OBJECTIVE: To explore the subjective experience of memory change in groups at risk of dementia (those with mild cognitive impairment MCI or high β-amyloid (Aβ+) burden) to determine the existence of potential phenomenological typologies. METHOD: We recruited 123 healthy controls (HC) and individuals with MCI from the Australian Imaging, Biomarker and Lifestyle (AIBL) study. Sixty-7 (HC = 47,MCI = 20) had Aβ scans available for analysis. Semistructured interviews were administered, transcribed, and meaningful phrases extracted from transcripts. Twelve themes were defined and compared across diagnostic status and Aβ status. RESULTS: MCI endorsed more complaints of burdensome coping strategies,..

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Funding Acknowledgements

The AIBL study ( received support from CSIRO, the Science and Industry Endowment Fund (, NHMRC and Dementia Collaborative Research Centres (DCRC), as well as Industry, including Pfizer, Merck, Janssen, and GE Health care. Colin Masters is a consultant for both Eli Lilly and Prana Biotechnology, as well as has stock ownership in Prana Biotechnology. This has not influenced the outcome of this paper. No other authors have anything to declare. We thank all the participants who took part in this study and the clinicians who referred MCI participants to the study.