Journal article

INVITRO RESPONSES OF HUMAN-PROSTATE TUMOR-CELL LINES TO A RANGE OF ANTI-TUMOR AGENTS

SA METCALFE, RDH WHELAN, JRW MASTERS, BT HILL

INTERNATIONAL JOURNAL OF CANCER | WILEY | Published : 1983

Abstract

Four human prostate tumour continuous cell lines were employed for in vitro drug sensitivity testing of nine cytotoxic drugs, X-irradiation and two hormonal preparations. Responses were assessed by measuring cell survival as judged by colony formation in agarose. A marked heterogeneity of responses was noted to many of the agents studied, including X-irradiation. However, in terms of ID70 values for 24-h drug exposures, comparable responses in all the cell lines tested, with values falling within a 1.4- to 2.9-fold range, were noted with actinomycin D, adriamycin, m-AMSA, dibromodulcitol, 5-fluorouracil, hydroxyurea and ICRF-159. In contrast, mixed responses to cis-platinum and methotrexate ..

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