Reprogramming Somatic Cells to a Kidney Fate
Minoru Takasato, Jessica M Vanslambrouck, Melissa H Little
SEMINARS IN NEPHROLOGY | W B SAUNDERS CO-ELSEVIER INC | Published : 2014
Recent years have challenged the view that adult somatic cells reach a state of terminal differentiation. Although the ultimate example of this, somatic cell nuclear transfer, has not proven feasible in human beings, dedifferentiation of mature cell types to a more primitive state, direct reprogramming from one mature state to another, and the reprogramming of any adult cell type to a pluripotent state via enforced expression of key transcription factors now all have been shown. The implications of these findings for kidney disease include the re-creation of key renal cell types from more readily available and expandable somatic cell sources. The feasibility of such an approach recently was ..View full abstract
Awarded by National Health and Medical Research Council of Australia
Awarded by National Health and Medical Research Council
Awarded by Australian Research Council
Supported by the National Health and Medical Research Council of Australia (Senior Principal Research Fellow grant to M.H.L., APP1042093), and by grants from the National Health and Medical Research Council (APP1041275, APP1041277), and Melissa Little and Minoru Takasato are participants in Stein Cells Australia, supported by the Australian Research Council (SRI110001002).