Journal article

Reprogramming Somatic Cells to a Kidney Fate

Minoru Takasato, Jessica M Vanslambrouck, Melissa H Little

SEMINARS IN NEPHROLOGY | W B SAUNDERS CO-ELSEVIER INC | Published : 2014

Abstract

Recent years have challenged the view that adult somatic cells reach a state of terminal differentiation. Although the ultimate example of this, somatic cell nuclear transfer, has not proven feasible in human beings, dedifferentiation of mature cell types to a more primitive state, direct reprogramming from one mature state to another, and the reprogramming of any adult cell type to a pluripotent state via enforced expression of key transcription factors now all have been shown. The implications of these findings for kidney disease include the re-creation of key renal cell types from more readily available and expandable somatic cell sources. The feasibility of such an approach recently was ..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Health and Medical Research Council


Awarded by Australian Research Council


Funding Acknowledgements

Supported by the National Health and Medical Research Council of Australia (Senior Principal Research Fellow grant to M.H.L., APP1042093), and by grants from the National Health and Medical Research Council (APP1041275, APP1041277), and Melissa Little and Minoru Takasato are participants in Stein Cells Australia, supported by the Australian Research Council (SRI110001002).