Journal article

MicroRNAs-140-5p/140-3p Modulate Leydig Cell Numbers in the Developing Mouse Testis

Joanna Rakoczy, Selene L Fernandez-Valverde, Evgeny A Glazov, Elanor N Wainwright, Tempei Sato, Shuji Takada, Alexander N Combes, Darren J Korbie, David Miller, Sean M Grimmond, Melissa H Little, Hiroshi Asahara, John S Mattick, Ryan J Taft, Dagmar Wilhelm

BIOLOGY OF REPRODUCTION | OXFORD UNIV PRESS INC | Published : 2013

Abstract

MicroRNAs (miRNAs) have been shown to play key regulatory roles in a range of biological processes, including cell differentiation and development. To identify miRNAs that participate in gonad differentiation, a fundamental and tightly regulated developmental process, we examined miRNA expression profiles at the time of sex determination and during the early fetal differentiation of mouse testes and ovaries using high-throughput sequencing. We identified several miRNAs that were expressed in a sexually dimorphic pattern, including several members of the let-7 family, miR-378, and miR-140-3p. We focused our analysis on the most highly expressed, sexually dimorphic miRNA, miR-140-3p, and found..

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Grants

Awarded by Australian Research Council (ARC)


Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by ARC Discovery Early Career Research Award


Awarded by Future Fellow of the ARC


Funding Acknowledgements

Supported by research grants from the Australian Research Council (ARC; grant DP0879913) and National Health and Medical Research Council of Australia (NHMRC; grant 631460). R.J.T is supported by an ARC Discovery Early Career Research Award (DE120101916). D.W. is a Future Fellow of the ARC (FT110100327).