Journal article

Identification of Novel Markers of Mouse Fetal Ovary Development

Huijun Chen, James S Palmer, Rathi D Thiagarajan, Marcel E Dinger, Emmanuelle Lesieur, Hansheng Chiu, Alexandra Schulz, Cassy Spiller, Sean M Grimmond, Melissa H Little, Peter Koopman, Dagmar Wilhelm

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2012

Abstract

In contrast to the developing testis, molecular pathways driving fetal ovarian development have been difficult to characterise. To date no single master regulator of ovarian development has been identified that would be considered the female equivalent of Sry. Using a genomic approach we identified a number of novel protein-coding as well as non-coding genes that were detectable at higher levels in the ovary compared to testis during early mouse gonad development. We were able to cluster these ovarian genes into different temporal expression categories. Of note, Lrrc34 and AK015184 were detected in XX but not XY germ cells before the onset of sex-specific germ cell differentiation marked by ..

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Grants

Awarded by NIDDK, National Institute of Health, United States of America


Awarded by Australian Research Council (ARC)


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

This work was supported by research grants from the NIDDK, National Institute of Health, United States of America, (http://www2.niddk.nih.gov/, DK070136), Australian Research Council (ARC, http://www.arc.gov.au/) (DP0879913) and National Health and Medical Research Council of Australia (NHMRC; http://www.nhmrc.gov.au/455902). DW and MED are CDA Fellows of the NHMRC (519737). ML is a Principal Research Fellow of the NHMRC. PK is an ARC Federation Fellow. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.