Reprogramming the kidney: a novel approach for regeneration
Caroline E Hendry, Melissa H Little
KIDNEY INTERNATIONAL | ELSEVIER SCIENCE INC | Published : 2012
Nuclear reprogramming has reshaped stem cell science and created new avenues for cell-based therapies. The ability to bestow any given phenotype upon adult cells regardless of their origin is an exciting possibility. How can this powerful tool be harnessed for the treatment of kidney disease? Many approaches, including induced pluripotent stem cell (iPSC) production, direct lineage conversion, and reprogramming to a kidney progenitor, are now possible. Indeed, the generation of iPSC lines from adult kidney-derived cells has been successfully achieved. This, however, is just the beginning of the challenge. This review will discuss the fundamental concepts of transcription factor-based reprogr..View full abstract
Awarded by National Institutes of Digestion Diabetes and Kidney, NIH
Awarded by NHMRC
Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
CEH was supported by a Rosamond Siemon Postgraduate Scholarship. MHL is a Principal Research Fellow of the National Health and Medical Research Council supported by the National Institutes of Digestion Diabetes and Kidney, NIH (DK070136, DK070136), the NHMRC (ID631362), and Australian Stem Cell Centre funding to MHL.