Journal article

Crim1 has an essential role in glycogen trophoblast cell and sinusoidal-trophoblast giant cell development in the placenta

DJ Pennisi, G Kinna, HS Chiu, DG Simmons, L Wilkinson, MH Little

PLACENTA | W B SAUNDERS CO LTD | Published : 2012

Abstract

Normal placental development and function is essential for fetal growth of eutherian mammals. Mutational studies have shown that numerous growth factors are required for placental development and differentiation of placental lineages. Here, using a gene-trap mutant mouse line, Crim1(KST264), we show that Crim1 is essential for murine placental development. Crim1 is a developmentally expressed, trans-membrane regulator of growth factor activity. Crim1(KST264/KST264) mutant placentae displayed hypoplasia from 13.5 dpc, and altered structure from 15.5 dpc, including alterations in cell number in both the junctional and labyrinth zones. Using the reporter gene from the Crim1(KST264) allele, we f..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by MHL


Funding Acknowledgements

We thank the staff of The University of Queensland Biological Resources animal facilities for support. This study conformed to the Institute's Animal Ethics Committee guidelines for animal use in research. This work was funded by Project Grants from the National Health and Medical Research Council of Australia to DJP (grant number 631658) and MHL (grant numbers 301056 and 455972).