Journal article
Renal organogenesis: What can it tell us about renal repair and regeneration?
MH Little
Organogenesis | TAYLOR & FRANCIS INC | Published : 2011
Abstract
The increasing prevalence of chronic kidney disease in the absence of new treatment modalities has become a strong driver for innovation in nephrology. An increasing understanding of stem cell biology has kindled the prospects of regenerative options for kidney disease. However, the kidney itself is not a regenerative organ, as all the nephrons are formed during embryonic development. Here, we will investigate advances in the molecular genetics of renal organogenesis, including what this can tell us about lineage relationships, and discuss how this may serve to inform us about both the normal processes of renal repair and options for regenerative therapies. © 2011 Landes Bioscience.
Grants
Awarded by National Institutes of Health
Funding Acknowledgements
M.L. is a Principal Research Fellow of the National Health and Medical Research Council. I acknowledge that this lecture presented research from past and present members of my research laboratory, including Grant Challen, Michael Lusis, Joan Li, Lorine Wilkinson, Fiona Rae, David Pennisi, Minoru Takasato, Caroline Hendry, Kylie Georgas, Han Sheng Chiu, Jessica Ineson, Norseha Suhaimi, Melissa Becroft and Bree Rumballe, and I thank them for their research efforts. I also acknowledge our collaborators within GUDMAP, notably, Sean Grimmond, Rathi Thiagarajan and Dave Tang at the University of Queensland. Aspects of this work have been supported by the National Institutes of Digestion Diabetes and Kidney, NIH (DK070136, DK070136), the NHMRC (ID45592) and the Australian Stem Cell Centre (P067, Stream 4.2) funding to M.L.Edited transcripts of research conferences sponsored by Organogenesis and the Washington University George M. O'Brien Center for Kidney Disease Research (P30 DK079333) are published in Organogenesis. These conferences cover organogenesis in all multicellular organisms including research into tissue engineering, artificial organs and organ substitutes and are participated in by faculty at Washington University School of Medicine, St. Louis, MO.