Expression of Metanephric Nephron-Patterning Genes in Differentiating Mesonephric Tubules
KM Georgas, HS Chiu, E Lesieur, BA Rumballe, Melissa H Little
DEVELOPMENTAL DYNAMICS | WILEY | Published : 2011
The metanephros is the functional organ in adult amniotes while the mesonephros degenerates. However, parallel tubulogenetic events are thought to exist between mesonephros and metanephros. Mesonephric tubules are retained in males and differentiate into efferent ducts of the male reproductive tract. By examining the murine mesonephric expression of markers of distinct stages and regions of metanephric nephrons during tubule formation and patterning, we provide further evidence to support this common morphogenetic mechanism. Renal vesicle, early proximal and distal tubule, loop of Henle, and renal corpuscle genes were expressed by mesonephric tubules. Vip, Slc6a20b, and Slc18a1 were male-spe..View full abstract
Awarded by NIH NIDDK
Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
Grant sponsor: NIH NIDDK; Grant number: DK070136.