Journal article

Expression of Metanephric Nephron-Patterning Genes in Differentiating Mesonephric Tubules

KM Georgas, HS Chiu, E Lesieur, BA Rumballe, Melissa H Little

DEVELOPMENTAL DYNAMICS | WILEY | Published : 2011

Abstract

The metanephros is the functional organ in adult amniotes while the mesonephros degenerates. However, parallel tubulogenetic events are thought to exist between mesonephros and metanephros. Mesonephric tubules are retained in males and differentiate into efferent ducts of the male reproductive tract. By examining the murine mesonephric expression of markers of distinct stages and regions of metanephric nephrons during tubule formation and patterning, we provide further evidence to support this common morphogenetic mechanism. Renal vesicle, early proximal and distal tubule, loop of Henle, and renal corpuscle genes were expressed by mesonephric tubules. Vip, Slc6a20b, and Slc18a1 were male-spe..

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