Defining and redefining the nephron progenitor population
Caroline Hendry, Bree Rumballe, Karen Moritz, Melissa H Little
PEDIATRIC NEPHROLOGY | SPRINGER | Published : 2011
It has long been appreciated that the mammalian kidney arises via reciprocal interactions between an epithelial ureteric epithelium and the surrounding metanephric mesenchyme. More recently, lineage tracing has confirmed that the portion of the metanephric mesenchyme closest to the advancing ureteric tips, the cap mesenchyme, represents the progenitor population for the nephron epithelia. This Six2(+)Cited1(+) population undergoes self-renewal throughout nephrogenesis while retaining the potential to epithelialize. In contrast, the Foxd1(+) portion of the metanephric mesenchyme shows no epithelial potential, developing instead into the interstitial, perivascular, and possibly endothelial ele..View full abstract
Awarded by National Health and Medical Research Council of Australia
Awarded by National institutes of Health
Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
We acknowledge Eleanor Wainwright and Dagmar Wilhelm for the images of Bcl2 protein localization within the developing kidney. We also acknowledge Kylie Georgas for technical assistance. CH is a Rosamond Siemon Postdoctoral Scholar. KM is a Senior Research Fellow and ML is a Principal Research Fellow with the National Health and Medical Research Council of Australia. The research of the authors is supported by the National Health and Medical Research Council of Australia (ID631362) and the National institutes of Health (DK070136).