Is There Such a Thing as a Renal Stem Cell?
Melissa H Little, John F Bertram
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | AMER SOC NEPHROLOGY | Published : 2009
Increasing interest in the potential of adult stem cells in regenerative medicine has led to numerous studies focused on the identification of endogenous renal stem cells within the mature mammalian kidney. A variety of approaches have been taken to identify such cells, including physical location, cell surface marker expression, and functional properties. Proof of clonogenicity or renal potential remains questionable, and few such populations have been characterized in humans; however, recent evidence that even podocytes, a cell type with limited proliferative capacity under normal conditions, are constantly regenerated from a population within the Bowman's capsule has breathed new life int..View full abstract
M.L. is a National Health and Medical Research Council Principal Research Fellow. The Australian Stem Cell Centre supports her work in this field.