Stem cell options for kidney disease
C Hopkins, J Li, F Rae, MH Little
JOURNAL OF PATHOLOGY | WILEY | Published : 2009
Chronic kidney disease (CKD) is increasing at the rate of 6-8% per annum in the US alone. At present, dialysis and transplantation remain the only treatment options. However, there is hope that stem cells and regenerative medicine may provide additional regenerative options for kidney disease. Such new treatments might involve induction of repair using endogenous or exogenous stem cells or the reprogramming of the organ to reinitiate development. This review addresses the current state of understanding with respect to the ability of non-renal stem cell sources to influence renal repair, the existence of endogenous renal stem cells and the biology of normal renal repair in response to damage...View full abstract
CH is a Rosamond Siemon Postgraduate Scholar. FR is a National Health and Medical Research Council Industry Fellow. ML is an honorary Research Fellow of the National Health and Medical Research Council and the Chief Scientific Officer of the Australian Stem Cell Centre. We thank Jess Ineson for images. We acknowledge the support of the Australian Stem Cell Centre.