Journal article

Crim1(KST264/KST264) mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development

Lorine Wilkinson, Thierry Gilbert, Genevieve Kinna, Leah-Anne Ruta, David Pennisi, Michelle Kett, Melissa H Little

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | AMERICAN SOCIETY NEPHROLOGY | Published : 2007

Abstract

Crim1, a transmembrane cysteine-rich repeat-containing protein that is related to chordin, plays a role in the tethering of growth factors at the cell surface. Crim1 is expressed in the developing kidney; in parietal cells, podocytes, and mesangial cells of the glomerulus; and in pericytes that surround the arterial vasculature. A gene-trap mouse line with an insertion in the Crim1 gene (Crim1(KST264/KST264)) displayed perinatal lethality with defects in multiple organ systems. This study further analyzed the defects that are present within the kidneys of these mice. Crim1(KST264/KST264) mice displayed abnormal glomerular development, illustrated by enlarged capillary loops, podocyte effacem..

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