Journal article

3 NONOVERLAPPING REGIONS OF CHROMOSOME ARM 11P ALLELE LOSS IDENTIFIED IN INFANTILE TUMORS OF ADRENAL AND LIVER

JA BYRNE, LA SIMMS, MH LITTLE, EM ALGAR, PJ SMITH

GENES CHROMOSOMES & CANCER | WILEY | Published : 1993

Abstract

Tumor and constitutional chromosome arm 11p genotypes were compared in 6 hepatoblastoma (HB) patients and 2 adrenal adenoma (AA) patients, with one HB patient and both AA patients displaying clinical features associated with the Beckwith-Wiedemann syndrome (BWS). Using up to 14 chromosome 11 polymorphic markers, loss of constitutional heterozygosity (LOH) was demonstrated in both AA patients and in 4 of 6 HB patients. This identified three distinct and non-overlapping regions of 11p within which LOH occurred, which were defined as lying distal to the gamma-globin locus (11p15.5), proximal to the gamma-globin locus but distal to 11p13 (LOH being detected at 11p15.1), and restricted to the 11p..

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