Three non‐overlapping regions of chromosome arm 11p allele loss identified in infantile tumors of adrenal and liver

Abstract

Tumor and constitutional chromosome arm 11p genotypes were compared in 6 hepatoblastoma (HB) patients and 2 adrenal adenoma (AA) patients, with one HB patient and both AA patients displaying clinical features associated with the Beckwith‐Wiedemann syndrome (BWS). Using up to 14 chromosome 11 polymorphic markers, loss of constitutional heterozygosity (LOH) was demonstrated in both AA patients and in 4 of 6 HB patients. This identified three distinct and non‐overlapping regions of 11p within which LOH occurred, which were defined as lying distal to the gamma‐globin locus (11p15.5), proximal to the gamma‐globin locus but distal to 11p13 (LOH being detected at 11p15.1), and restricted to the 11p..