Journal article

Sex Determination Directs Uniparental Mitochondrial Inheritance in Phycomyces

Viplendra PS Shakya, Alexander Idnurm

EUKARYOTIC CELL | AMER SOC MICROBIOLOGY | Published : 2014

Abstract

Uniparental inheritance (UPI) of mitochondria is common among eukaryotes. The underlying molecular basis by which the sexes of the parents control this non-Mendelian pattern of inheritance is yet to be fully understood. Two major factors have complicated the understanding of the role of sex-specific genes in the UPI phenomenon: in many cases (i) fusion occurs between cells of unequal size or (ii) mating requires a large region of the genome or chromosome that includes genes unrelated to sex determination. The fungus Phycomyces blakesleeanus is a member of the Mucoromycotina and has a simple mating type locus encoding only one high-mobility group (HMG) domain protein, and mating occurs by fus..

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University of Melbourne Researchers