Journal article
Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication
LJ Ma, AS Ibrahim, C Skory, MG Grabherr, G Burger, M Butler, M Elias, A Idnurm, BF Lang, T Sone, A Abe, SE Calvo, LM Corrochano, R Engels, J Fu, W Hansberg, JM Kim, CD Kodira, MJ Koehrsen, B Liu Show all
Plos Genetics | PUBLIC LIBRARY SCIENCE | Published : 2009
Open access
Abstract
Rhizopus oryzae is the primary cause of mucormycosis, an emerging, life-threatening infection characterized by rapid angioinvasive growth with an overall mortality rate that exceeds 50%. As a representative of the paraphyletic basal group of the fungal kingdom called "zygomycetes," R. oryzae is also used as a model to study fungal evolution. Here we report the genome sequence of R. oryzae strain 99-880, isolated from a fatal case of mucormycosis. The highly repetitive 45.3 Mb genome assembly contains abundant transposable elements (TEs), comprising approximately 20% of the genome. We predicted 13,895 protein-coding genes not overlapping TEs, many of which are paralogous gene pairs. The order..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
The genome sequencing of R. oryzae was funded by the National Human Genome Research Institute (NHGRI) (http://www.genome.gov/) and conducted at the Broad Institute of MIT and Harvard. This work was also supported by R01 AI063503 to ASI and PR054228 to BLW. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.