Journal article
A Large-Scale, Consortium-Based Genomewide Association Study of Asthma
Miriam F Moffatt, Ivo G Gut, Florence Demenais, David P Strachan, Emmanuelle Bouzigon, Simon Heath, Erika von Mutius, Martin Farrall, Mark Lathrop, William OCM Cookson, Ashish Kumar, Peter Burney, Debbie Jarvis, Matthias Wjst, Manolis Kogevinas, Rain Jogi, Christer Janson, Karl A Franklin, Ernst Omenaas, Benedicte Leynaert Show all
NEW ENGLAND JOURNAL OF MEDICINE | MASSACHUSETTS MEDICAL SOC | Published : 2010
Abstract
BACKGROUND: Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked to disease. METHODS: We carried out a genomewide association study by genotyping 10,365 persons with physician-diagnosed asthma and 16,110 unaffected persons, all of whom were matched for ancestry. We used random-effects pooled analysis to test for association in the overall study population and in subgroups of subjects with childhood-onset asthma (defined as asthma..
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Awarded by European Commission
Awarded by Wellcome Trust
Awarded by MRC
Funding Acknowledgements
Supported by a contract from the European Commission (018996) and grants from the French Ministry of Research, the Wellcome Trust (WT084703MA), and Asthma UK.