Journal article
Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians
JC Chambers, Z Weihua, D Zabaneh, J Sehmi, P Jain, MI McCarthy, P Froguel, A Ruokonen, D Balding, MR Jarvelin, J Scott, P Elliott, JS Kooner
Diabetes | AMER DIABETES ASSOC | Published : 2009
DOI: 10.2337/db08-1805
Abstract
OBJECTIVE - Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians. RESEARCH DESIGN AND METHODS - We carried out genome-wide association studies for fasting glucose in 5,089 nondiabetic Indian Asians genotyped with the Illumina Hap610 BeadChip and 2,385 Indian Asians (698 with type 2 diabetes) genotyped with the Illumina 300 BeadChip. Results were compared with findings in 4,462 European Caucasians. RESULTS - We identified three single nucleotide polymorphisms (SNPs) associated with glucose among Indian Asians at P < 5 ..
View full abstractGrants
Awarded by National Institute of Mental Health
Funding Acknowledgements
The LOLIPOP study was supported by the British Heart Foundation (SP/04/002) and the Wellcome Trust. NFBC1966 study was supported by the Academy of Finland (104781), the Medical Research Council (G0500539), University Hospital Oulu, Biocenter, University of Oulu, Finland, National Heart, Lung and Blood Institute Grant 5R01HL087679-02 through the SNP Typing for Association with Multiple Phenotypes from Existing Epidemiological Data (STAMPEED) program (1RL1MH083268-01) and the Wellcome Trust (Project Grant GR069224). The DNA extractions, sample quality control subjects, biobank up-keeping, and aliquotting were performed in the national Public Health Institute, Biomedicum. Helsinki, Finland and supported financially by the Academy of Finland (120315) and Biocentrum Helsinki. For NFBC1966 the wide genotyping was conducted by the Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts.r No potential conflicts of interest relevant to this article were reported.r We thank Nelson Freimer, Leena Peltonen, and the research teams involved in LOLIPOP and NFBC1966.