Journal article

Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance

Guy Leschziner, Delilah Zabaneh, M Pirmohamed, Andrew Owen, Jane Rogers, Alison J Coffey, David J Balding, David B Bentley, Michael R Johnson

PHARMACOGENETICS AND GENOMICS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2006

Abstract

BACKGROUND: The ATP-binding cassette (ABC) proteins are a superfamily of efflux pumps implicated as a mechanism for multidrug resistance in cytotoxic chemotherapy, immunosuppressive therapy, HIV and epilepsy. Genetic variation in P-glycoprotein, the product of the ABCB1 gene, is proposed to mediate de novo drug resistance, but associations between polymorphisms in ABCB1 and pharmacoresistance have produced conflicting results. Potential explanations for the inconsistency of results include inadequate characterization of gene structure, variation and linkage disequilibrium (LD) in ABCB1, as well as overlap in substrate specificity between ABCB1 and the various other drug transporters. METHODS..

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University of Melbourne Researchers