Journal article

Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study

Guy Leschziner, Andrea L Jorgensen, Toby Andrew, Munir Pirmohaomed, Paula R Williamson, Anthony G Marson, Alison J Coffey, Claire Middleditch, Jane Rogers, David R Bentley, David W Chadwick, David J Balding, Michael R Johnson



BACKGROUND: The ABCB1 3435C-->T single-nucleotide polymorphism (SNP) or a three-SNP haplotype containing 3435C-->T has been implicated in multidrug resistance in epilepsy in three retrospective case-control studies, but a further three have failed to replicate the association. We aimed to determine the effect of the ABCB1 gene on epilepsy drug response, using a unique large cohort of epilepsy patients with prospectively measured seizure and drug response outcomes. METHODS: The ABCB1 3435C-->T polymorphism and three-SNP haplotype, plus a comprehensive set of tag SNPs across ABCB1 and adjacent ABCB4, were genotyped in a cohort of 503 epilepsy patients with prospectively measured seizure and dr..

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University of Melbourne Researchers