Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study

Abstract

Background: The ABCB1 3435C→T single-nucleotide polymorphism (SNP) or a three-SNP haplotype containing 3435C→T has been implicated in multidrug resistance in epilepsy in three retrospective case-control studies, but a further three have failed to replicate the association. We aimed to determine the effect of the ABCB1 gene on epilepsy drug response, using a unique large cohort of epilepsy patients with prospectively measured seizure and drug response outcomes. Methods: The ABCB1 3435C→T polymorphism and three-SNP haplotype, plus a comprehensive set of tag SNPs across ABCB1 and adjacent ABCB4, were genotyped in a cohort of 503 epilepsy patients with prospectively measured seizure and drug res..