Journal article

Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach

Guy D Leschziner, Toby Andrew, John Paul Leach, David Chadwick, Alison J Coffey, David J Balding, David R Bentley, Munir Pirmohamed, Michael R Johnson

PHARMACOGENETICS AND GENOMICS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2007

Abstract

P-glycoprotein, the product of the ABCB1 gene, is a proposed mechanism of pharmacoresistance in epilepsy. Previous attempts to correlate the ABCB1 C3435T SNP, or a three-SNP haplotype containing C3435T with epilepsy pharmacoresistance have produced discordant findings. We analysed these single nucleotide polymorphisms (SNPs), plus a more comprehensive set of tagging SNPs describing common variation in ABCB1 in a case-control study. No significant association of C3435T (P=0.55), the three-SNP haplotype (lowest P=0.14) or any gene-wide tagging SNP (lowest P=0.17) with multidrug resistance in epilepsy was identified. Meta-analysis of studies using the same definition of multidrug resistance (n=..

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