Journal article
A genome-wide association study identifies novel risk loci for type 2 diabetes
R Sladek, G Rocheleau, J Rung, C Dina, L Shen, D Serre, P Boutin, D Vincent, A Belisle, S Hadjadj, B Balkau, B Heude, G Charpentier, TJ Hudson, A Montpetit, AV Pshezhetsky, M Prentki, BI Posner, DJ Balding, D Meyre Show all
Nature | Published : 2007
DOI: 10.1038/nature05616
Abstract
Type 2 diabetes mellitus results from the interaction of environmental factors with a combination of genetic variants, most of which were hitherto unknown. A systematic search for these variants was recently made possible by the development of high-density arrays that permit the genotyping of hundreds of thousands of polymorphisms. We tested 392,935 single-nucleotide polymorphisms in a French case-control cohort. Markers with the most significant difference in genotype frequencies between cases of type 2 diabetes and controls were fast-tracked for testing in a second cohort. This identified four loci containing variants that confer type 2 diabetes risk, in addition to confirming the known as..
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