Journal article

DESIGN AND ANALYSIS OF CHROMOSOME PHYSICAL MAPPING EXPERIMENTS

DJ BALDING

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | ROYAL SOC | Published : 1994

Abstract

Mathematical and statistical aspects of constructing ordered-clone physical maps of chromosomes are reviewed. Three broad problems are addressed: analysis of fingerprint data to identify configurations of overlapping clones, prediction of the rate of progress of a mapping strategy and optimal design of pooling schemes for screening large clone libraries.

University of Melbourne Researchers