Journal article

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

Kate E Lawlor, Nufail Khan, Alison Mildenhall, Motti Gerlic, Ben A Croker, Akshay A D'Cruz, Cathrine Hall, Sukhdeep Kaur Spall, Holly Anderton, Seth L Masters, Maryam Rashidi, Ian P Wicks, Warren S Alexander, Yasuhiro Mitsuuchi, Christopher A Benetatos, Stephen M Condon, W Wei-Lynn Wong, John Silke, David L Vaux, James E Vince

Nature Communications | NATURE PUBLISHING GROUP | Published : 2015


Awarded by National Health and Medical Research (Canberra, Australia) Project

Awarded by SNF

Funding Acknowledgements

We thank Vishva Dixit for Ripk<SUP>3-/-</SUP> mice, Michelle Kelliher for Ripk1<SUP>-/-</SUP> mice, Heinrich Korner for Tnf<SUP>-/-</SUP> and Stephen Hedrick for Casp8<SUP>fl/fl</SUP> mice; Lisa Lindqvist and Thomas Naderer for critically reading the manuscript and James Murphy for scientific discussions; E. Tsui for preparation of histology; N. Lynch, K. Trueman, L. Kyran, K. Vella, L. Scott, C. Yates for animal care; S. Monard and staff for cell sorting; J. Corbin for Advia cell counts; K. Rogers, J. O'Donnell and K. McArthur for assistance with imaging; Thomas Haimowitz and Yijun Deng for IAP antagonist synthesis and structural information. This work was supported by National Health and Medical Research (Canberra, Australia) Project grants (1051210, 1025594, 1057905), fellowships (J.E.V. (1052598), I.P.W. (1023407), J.S. (541901)) and Program Grants (1016647 and 461221) and operational infrastructure grants through the Australian Government IRISS and the Victorian State Government OIS. W.W-L.W. was supported by a SNF grant (310030138085) and I.P.W. by the Reid Charitable Trusts.