Journal article

Sharpin is a key regulator of skeletal homeostasis in a TNF-dependent manner

HW McGowan, JA Schuijers, BL Grills, SJ McDonald, JA Rickard, J Silke, AC McDonald

JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS | JMNI | Published : 2014

Abstract

OBJECTIVES: SHARPIN is a subunit of LUBAC and regulates activation of NF-κB, a pivotal transcription factor in skeletal homeostasis. Mutated SHARPIN gene (cpdm) mice develop chronic proliferative dermatitis and systemic inflammation. Cpdm mice have an osteopaenic phenotype characterised by decreased cortical and trabecular bone volume, but whether this is a consequence of the hyper-inflammatory phenotype is unknown. The inflammatory phenotype of cpdm mice is prevented by Tnf deficiency so we examined cpdm.Tnf (-/-) mice to examine the role of SHARPIN in skeletal development. METHODS: This research determined the extent to which SHARPIN and TNF interact within the skeleton through analyses of..

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University of Melbourne Researchers