Inhibitor of Apoptosis (IAP) Proteins-Modulators of Cell Death and Inflammation
John Silke, Pascal Meier
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT | Published : 2013
Misregulated innate immune signaling and cell death form the basis of much human disease pathogenesis. Inhibitor of apoptosis (IAP) protein family members are frequently overexpressed in cancer and contribute to tumor cell survival, chemo-resistance, disease progression, and poor prognosis. Although best known for their ability to regulate caspases, IAPs also influence ubiquitin (Ub)-dependent pathways that modulate innate immune signaling via activation of nuclear factor κB (NF-κB). Recent research into IAP biology has unearthed unexpected roles for this group of proteins. In addition, the advances in our understanding of the molecular mechanisms that IAPs use to regulate cell death and inn..View full abstract
Awarded by Medical Research Council
Our apologies to those whose work could not be cited or were cited only indirectly owing to space limitations. We would like to thank members of the Meier and Silke Labs for support. We acknowledge NHS funding to the NIHR Biomedical Research Centre, Victorian State Government Operational Infrastructure Support, and Australian Government NHMRC and NHMRC IRIISS funding.