Plasma, salivary and urinary cortisol levels following physiological and stress doses of hydrocortisone in normal volunteers
Caroline Jung, Santo Greco, Hanh HT Nguyen, Jui T Ho, John G Lewis, David J Torpy, Warrick J Inder
BMC ENDOCRINE DISORDERS | BMC | Published : 2014
BACKGROUND: Glucocorticoid replacement is essential in patients with primary and secondary adrenal insufficiency, but many patients remain on higher than recommended dose regimens. There is no uniformly accepted method to monitor the dose in individual patients. We have compared cortisol concentrations in plasma, saliva and urine achieved following "physiological" and "stress" doses of hydrocortisone as potential methods for monitoring glucocorticoid replacement. METHODS: Cortisol profiles were measured in plasma, saliva and urine following "physiological" (20 mg oral) or "stress" (50 mg intravenous) doses of hydrocortisone in dexamethasone-suppressed healthy subjects (8 in each group), comp..View full abstract
Dr Caroline Jung has received a research grant from St Vincent's Hospital, Victoria, and Australian Postgraduate Award Scholarship from the University of Melbourne.