The Association of Longitudinal Trend of Fasting Plasma Glucose With Retinal Microvasculature in People Without Established Diabetes
Yin Hu, Yong Niu, Dandan Wang, Ying Wang, Brien A Holden, Mingguang He
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2015
PURPOSE: Structural changes of retinal vasculature, such as altered retinal vascular calibers, are considered as early signs of systemic vascular damage. We examined the associations of 5-year mean level, longitudinal trend, and fluctuation in fasting plasma glucose (FPG) with retinal vascular caliber in people without established diabetes. METHODS: A prospective study was conducted in a cohort of Chinese people age ≥40 years in Guangzhou, southern China. The FPG was measured at baseline in 2008 and annually until 2012. In 2012, retinal vascular caliber was assessed using standard fundus photographs and validated software. A total of 3645 baseline nondiabetic participants with baseline and f..View full abstract
Awarded by Fundamental Research Funds of the State Key Laboratory in Ophthalmology, National Natural Science Foundation of China
Supported by the Fundamental Research Funds of the State Key Laboratory in Ophthalmology, National Natural Science Foundation of China (81125007) and a research grant from the Brien Holden Vision Institute. The authors alone are responsible for the content and writing of the paper.