Journal article

Analysis of the ghrelin receptor-independent vascular actions of ulimorelin

John Broad, Brid Callaghan, Gareth J Sanger, James A Brock, John B Furness

EUROPEAN JOURNAL OF PHARMACOLOGY | ELSEVIER SCIENCE BV | Published : 2015

Abstract

Ulimorelin (TZP101) is a ghrelin receptor agonist that stimulates intestinal motility, but also reduces blood pressure in rodents and humans and dilates blood vessels. It has been proposed as a treatment for intestinal motility disorders. Here we investigated the mechanisms through which ulimorelin affects vascular diameter. Actions of ulimorelin on wall tension of rodent arteries were investigated and compared with other ghrelin receptor agonists. Saphenous, mesenteric and basilar arteries were obtained from Sprague-Dawley rats (male, 8 weeks) and saphenous arteries were obtained from wild type or ghrelin receptor null mice. These were mounted in myography chambers to record artery wall ten..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Transport Accident Commission through the Institute for Safety Compensation and Recovery Research


Funding Acknowledgements

John Broad was supported by the Outstanding Young Investigator Award of the British Pharmacological Society and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. Research support was provided by the National Health and Medical Research Council of Australia (Project Grant 1005811) and the Transport Accident Commission through the Institute for Safety Compensation and Recovery Research (Grant N-13-085).