Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability

Vinojini B Nair; Ross AD Bathgate; Frances Separovic; Chrishan S Samuel; Mohammed Akhter Hossain; John D Wade

Journal article

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability

Vinojini B Nair, Ross AD Bathgate, Frances Separovic, Chrishan S Samuel, Mohammed Akhter Hossain, John D Wade

BIOMED RESEARCH INTERNATIONAL | HINDAWI LTD | Published : 2015

DOI: 10.1155/2015/731852

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University of Melbourne Researchers

Frances Separovic Author Chemistry

Akhter Hossain Author Florey Department of Neuroscience and Mental Health

Chrishan Samuel Author Biochemistry and Pharmacology

Ross Bathgate Author Florey Department of Neuroscience and Mental Health

John Wade Author Florey Department of Neuroscience and Mental Health

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia Project

Funding Acknowledgements

This research was partially funded by National Health and Medical Research Council (NHMRC) of Australia Project Grants 508995 and 1023078 to John D. Wade, Mohammed Akhter Hossain, and Ross A. D. Bathgate. The authors thank Tania Ferraro and Sharon Layfield for their assistance in undertaking the biological assays. Mohammed Akhter Hossain was the recipient of a Florey Foundation Fellowship and Ross A. D. Bathgate (APP1042650) and Chrishan S. Samuel (APP1041766) are NHMRC Senior Research Fellows, and John D. Wade (APP5018148) is an NHMRC Principal Research Fellow. Research at The Florey Institute of Neuroscience and Mental Health is supported by the Victorian Government Operational Infrastructure Support Program.