Journal article

Convergent evidence for mGluR5 in synaptic and neuroinflammatory pathways implicated in ASD

Daniela Zantomio, Gursharan Chana, Liliana Laskaris, Renee Testa, Ian Everall, Christos Pantelis, Efstratios Skafidas

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2015

Abstract

The pathogenesis of Autism Spectrum Disorder (ASD), a serious neurodevelopmental disorder, is poorly understood. We review evidence for alterations in glutamatergic signalling in the aetiology of ASD, with a focus on the metabotropic glutamate receptor-5 (mGluR5). mGluR5 signalling is important for synapse formation, neuroplasticity and long term potentiation as well as neuroprotection and has been shown to have a regulatory role in neuroinflammation. Evidence for neuroinflammation in ASD is supported by increase in pro-inflammatory cytokines in the blood and cerebrospinal fluid (CSF) and increased number and activation of microglia in postmortem dorsolateral prefrontal cortex (DLPFC). mGlur..

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