PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning

Timothy Johanssen; Nuttawat Suphantarida; Paul S Donnelly; Xiang M Liu; Steven Petrou; Andrew F Hill; Kevin J Barnham

Journal article

PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning

Timothy Johanssen, Nuttawat Suphantarida, Paul S Donnelly, Xiang M Liu, Steven Petrou, Andrew F Hill, Kevin J Barnham

NEUROBIOLOGY OF DISEASE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2015

DOI: 10.1016/j.nbd.2015.02.008

Abstract

Excitotoxicity is the pathological process by which neuronal death occurs as a result of excessive stimulation of receptors at the excitatory synapse such as the NMDA receptor (NMDAR). Excitotoxicity has been implicated in the acute neurological damage from ischemia and traumatic brain injury and in the chronic neurodegeneration in Alzheimer's disease (AD) and Huntington's disease (HD). As a result NMDAR antagonists have become an attractive therapeutic strategy for the potential treatment of multiple neurodegenerative diseases. However NMDAR signaling is dichotomous in nature, with excessive increases in neuronal intracellular calcium through excessive NMDAR activity being lethal but modera..

View full abstract

University of Melbourne Researchers

Steven Petrou Author Florey Department of Neuroscience and Mental Health

Paul Donnelly Author Chemistry

Related Projects (3)

DISEASES OF THE AGEING BRAIN

The Neurodegeneration Program is discovering the basic pathways that cause Alzheimer’s disease and related diseases of the aging brain; from..

EPILEPSY: A 'PATIENT TO BENCH AND BACK TO PATIENT' PROGRAM ABOUT UNDERSTANDING THE CAUSES OF SEIZURE DISORDERS.

The team is comprised of neurologists, molecular geneticists, physiologists and brain imaging specialists and leads the world in the discove..

Novel therapies for neurodegenerative diseases

Exitotoxicity has been implicated in many neurological disorders incluing Alzheimer's and Huntington's disesaes. This toxicity can be inhibi..

Grants

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (Program Grant 628946 to AFH, KJB: Senior Research Fellowship APP1002373 to KJB, Project Grant APP1031193 to KJB, PSD Program Grant 628952 and Senior Research Fellowship 100505 to SP) and by the Victorian Government through the Operational Infrastructure Scheme. T.J. received PhD scholarships from the National Health & Medical Research Council and Commonwealth Scientific & Industrial Research Organisation of Australia.