PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning
Timothy Johanssen, Nuttawat Suphantarida, Paul S Donnelly, Xiang M Liu, Steven Petrou, Andrew F Hill, Kevin J Barnham
NEUROBIOLOGY OF DISEASE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2015
Excitotoxicity is the pathological process by which neuronal death occurs as a result of excessive stimulation of receptors at the excitatory synapse such as the NMDA receptor (NMDAR). Excitotoxicity has been implicated in the acute neurological damage from ischemia and traumatic brain injury and in the chronic neurodegeneration in Alzheimer's disease (AD) and Huntington's disease (HD). As a result NMDAR antagonists have become an attractive therapeutic strategy for the potential treatment of multiple neurodegenerative diseases. However NMDAR signaling is dichotomous in nature, with excessive increases in neuronal intracellular calcium through excessive NMDAR activity being lethal but modera..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was supported by the National Health and Medical Research Council of Australia (Program Grant 628946 to AFH, KJB: Senior Research Fellowship APP1002373 to KJB, Project Grant APP1031193 to KJB, PSD Program Grant 628952 and Senior Research Fellowship 100505 to SP) and by the Victorian Government through the Operational Infrastructure Scheme. T.J. received PhD scholarships from the National Health & Medical Research Council and Commonwealth Scientific & Industrial Research Organisation of Australia.