The IRONMAN trial: a protocol for a multicentre randomised placebo-controlled trial of intravenous iron in intensive care unit patients with anaemia
Edward Litton, Stuart Baker, Wendy Erber, Craig French, Janet Ferrier, David Hawkins, Alisa M Higgins, Axel Hofmann, Bart L De Keulenaer, Shannon Farmer, Julie McMorrow, John Olynyk, Toby Richards, Simon Towler, Steve Webb
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine | AUSTRALASIAN MED PUBL CO LTD | Published : 2014
BACKGROUND: Allogeneic red blood cell (RBC) transfusion is associated with significant increases in mortality and major morbidity in patients admitted to the intensive care unit, and the blood supplies it requires are an increasingly scarce and costly resource. Despite high levels of compliance with recommended transfusion thresholds in the ICU, RBC transfusion remains common. Novel interventions to reduce the incidence of RBC transfusion are required. OBJECTIVE: To describe the study protocol for a randomised controlled trial, the Intravenous Iron or Placebo for Anaemia in Intensive Care (IRONMAN) trial, comparing intravenous (IV) iron with placebo in patients who are admitted to an ICU and..View full abstract
This study has been funded by a grant from the Western Australian State Health Research Advisory Council. The study drug will be supplied by Vifor Pharma according to a letter of understanding reviewed and agreed upon by Royal Perth Hospital and adhering to the principles of scientific independence in the conduct and reporting of the trial. The study is endorsed by the Australian and New Zealand Intensive Care Society Clinical Trials Group and is part of the Centre of Research Excellence for Patient Blood Management in Critical Illness and Trauma.