Impact of acute rejection therapy on infections and malignancies in renal transplant recipients

Abstract

Background. Infections and malignancies are important causes of mortality and morbidity in renal allograft recipients. Their risk increases with increasing immunosuppression. Methods. In an attempt to quantitate the increase in the risk of these complications in association with antirejection therapy, we reviewed the records of all renal allograft recipients of our center transplanted during the cyclosporin era. We sub-divided the patients into three groups based on acute rejection episodes during the first 6 months posttransplant, and the treatment for acute rejection: those who did not develop AR - group 1 (n=168); those who had one or more episodes of acute rejection and were treated with..