Journal article

Risk factors for late renal allograft dysfunction: Effects of baseline glomerular size

MX Li, KM Nicholls, GJ Becker

JOURNAL OF NEPHROLOGY | SPRINGER HEIDELBERG | Published : 2002

Abstract

BACKGROUND: Both alloantigen dependent and alloantigen independent factors contribute to late allograft dysfunction. Among the latter, the importance of the mass of the donor kidney is an issue of interest. We hypothesized that glomerular hypertrophy is a risk factor for deterioration of allograft function. The goal of this study was to examine the role of glomerular size in predicting late allograft dysfunction. METHODS: All baseline graft biopsies between 1990 and 1998 were reviewed and sections containing at least 15 glomeruli were selected for morphometric analyses. Glomerular size was measured using the maximal profile area (MPA) method. Linear correlations between creatinine clearance ..

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