Journal article

The Course of Neuropsychiatric Symptoms in Dementia: A 3-Year Longitudinal Study

Henry Brodaty, Michael H Connors, Jing Xu, Michael Woodward, David Ames

Journal of the American Medical Directors Association | ELSEVIER SCIENCE INC | Published : 2015


OBJECTIVES: Patients with dementia experience a wide range of neuropsychiatric symptoms. These symptoms often cause considerable distress to patients and caregivers, and often contribute to institutionalization. The current study examined the prevalence and course of neuropsychiatric symptoms in a large sample of patients with dementia attending memory clinics. DESIGN: Three-year nonprescriptive, observational study examining relationships between predictors and outcome variables in patients with dementia. SETTING: Nine memory clinics around Australia. PARTICIPANTS: Of 970 patients recruited, 779 patients had dementia at baseline. MEASUREMENTS: Over 3 years, patients were rated on 6 occasion..

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Funding Acknowledgements

The Dementia Collaborative Research Center is funded by the National Health and Medical Research Council. The authors thank all the Australian investigators, study nurses, staff, and hospitals who comprise the PRIME study group: Prince of Wales Hospital (Marika Donkin, Kim Burns, Katrin Seeher); The Queen Elizabeth Hospital (Shelley Casey, Trish Steventon); St George's Hospital (Maree Mastwyk, Alissa Westphal, Nicola Lautenschlager, Olga Yastrubetskaya, Marilyn Kemp, Edmond Chiu and Jennifer Ames); Austin Health Repatriation Hospital (Irene Tan, Henry Zeimer, Leonie Johnston); Hornsby Ku-Ring-Gai Hospital (Sue Kurrle, Roseanne Hogarth, Judith Allan); Fremantle Hospital (Roger Clarnette, Janice Guy, Denae Clark); The Prince Charles Hospital (Chris Davis, Mary Wyatt, Katrina Brosnan, Margaret Morton); Rankin Park Hospital (John Ward, Jeanette Gatgens); and Geelong Private Hospital (Alastair Mander, Bernadine Charles). The authors also thank the patients and caregivers who supported the study.