Cognitive Dysfunction in Depression - Pathophysiology and Novel Targets
Andre F Carvalho, Kamilla K Miskowiak, Thomas N Hyphantis, Cristiano A Koehler, Gilberto S Alves, Beatrice Bortolato, Paulo Marcelo G Sales, Rodrigo Machado-Vieira, Michael Berk, Roger S McIntyre
CNS & Neurological Disorders - Drug Targets | BENTHAM SCIENCE PUBL | Published : 2014
Major depressive disorder (MDD) is associated with cognitive dysfunction encompassing several domains, including memory, executive function, processing speed and attention. Cognitive deficits persist in a significant proportion of patients even in remission, compromising psychosocial functioning and workforce performance. While monoaminergic antidepressants may improve cognitive performance in MDD, most antidepressants have limited clinical efficacy. The overarching aims of this review were: (1) to synthesize extant literature on putative biological pathways related to cognitive dysfunction in MDD and (2) to review novel neurotherapeutic targets for cognitive enhancement in MDD. We found tha..View full abstract
AFC is supported by a research fellowship award from Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq; Level II). CAK is supported by a postdoctoral fellowship from CAPES.