Journal article
Genetic and environmental variances of bone microarchitecture and bone remodeling markers: a twin study
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research | Published : 2015
DOI: 10.1002/jbmr.2365
Abstract
© 2014 American Society for Bone and Mineral Research. All genetic and environmental factors contributing to differences in bone structure between individuals mediate their effects through the final common cellular pathway of bone modeling and remodeling. We hypothesized that genetic factors account for most of the population variance of cortical and trabecular microstructure, in particular intracortical porosity and medullary size - void volumes (porosity), which establish the internal bone surface areas or interfaces upon which modeling and remodeling deposit or remove bone to configure bone microarchitecture. Microarchitecture of the distal tibia and distal radius and remodeling markers w..
View full abstractGrants
Awarded by National Health & Medical Research Council (NHMRC) of Australia
Awarded by Research Council of Norway (RCN)
Funding Acknowledgements
This research was facilitated through access to the Australian Twin Registry, a national resource supported by an Enabling Grant (ID 628911) from the National Health & Medical Research Council (NHMRC) of Australia. This study was funded by NHMRC and by the Research Council of Norway (RCN) Grant (ID 178588/V50).