Journal article

Ventilation Onset Prior to Umbilical Cord Clamping (Physiological-Based Cord Clamping) Improves Systemic and Cerebral Oxygenation in Preterm Lambs

Graeme R Polglase, Jennifer A Dawson, Martin Kluckow, Andrew W Gill, Peter G Davis, Arjan B te Pas, Kelly J Crossley, Annie McDougall, Euan M Wallace, Stuart B Hooper

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2015

Abstract

BACKGROUND: As measurement of arterial oxygen saturation (SpO2) is common in the delivery room, target SpO2 ranges allow clinicians to titrate oxygen therapy for preterm infants in order to achieve saturation levels similar to those seen in normal term infants in the first minutes of life. However, the influence of the onset of ventilation and the timing of cord clamping on systemic and cerebral oxygenation is not known. AIM: We investigated whether the initiation of ventilation, prior to, or after umbilical cord clamping, altered systemic and cerebral oxygenation in preterm lambs. METHODS: Systemic and cerebral blood-flows, pressures and peripheral SpO2 and regional cerebral tissue oxygenat..

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Grants

Awarded by National Institute of Health


Awarded by National Health and Medical Research Council (NHMRC)


Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT


Funding Acknowledgements

This research was supported by National Institute of Health R01HD072848-01A1, National Health and Medical Research Council (NHMRC) Project Grant (1067615), NHMRC Research Fellowships (GRP: 1026890, JAD: APP1012686, PGD: APP1059111 and SBH: APP1058537), a Rebecca L. Cooper Medical Research Foundation Fellowship, Financial Markets for Children Research Grant (GRP) and the Victorian Government's Operational Infrastructure Support Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.