Journal article

Decreased STAT3 in human idiopathic fetal growth restriction contributes to trophoblast dysfunction

AJ Borg, HEJ Yong, M Lappas, SA Degrelle, RJ Keogh, F Da Silva-Costa, T Fournier, M Abumaree, JA Keelan, B Kalionis, P Murthi



Abnormal trophoblast function is associated with fetal growth restriction (FGR). The JAK-STAT pathway is one of the principal signalling mechanisms by which cytokines and growth factors modulate cell proliferation, differentiation, cell migration and apoptosis. The expression of placental JAK-STAT genes in human idiopathic FGR is unknown. In this study, we propose the hypothesis that JAK-STAT pathway genes are differentially expressed in idiopathic FGR-affected pregnancies and contribute to abnormal feto-placental growth by modulating the expression of the amino acid transporter SNAT2, differentiation marker CGB/human chorionic gonadotrophin beta-subunit (β-hCG) and apoptosis markers caspase..

View full abstract