Acquisition of Antibodies against Plasmodium falciparum Merozoites and Malaria Immunity in Young Children and the Influence of Age, Force of Infection, and Magnitude of Response
Danielle I Stanisic, Freya JI Fowkes, Melanie Koinari, Sarah Javati, Enmoore Lin, Benson Kiniboro, Jack S Richards, Leanne J Robinson, Louis Schofield, James W Kazura, Christopher L King, Peter Zimmerman, Ingrid Felger, Peter M Siba, Ivo Mueller, James G Beeson
Infection and Immunity | AMER SOC MICROBIOLOGY | Published : 2015
Individuals in areas of Plasmodium falciparum endemicity develop immunity to malaria after repeated exposure. Knowledge of the acquisition and nature of protective immune responses to P. falciparum is presently limited, particularly for young children. We examined antibodies (IgM, IgG, and IgG subclasses) to merozoite antigens and their relationship to the prospective risk of malaria in children 1 to 4 years of age in a region of malaria endemicity in Papua New Guinea. IgG, IgG1, and IgG3 responses generally increased with age, were higher in children with active infection, and reflected geographic heterogeneity in malaria transmission. Antigenic properties, rather than host factors, appeare..View full abstract
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
This work was supported by the National Health and Medical Research Council of Australia (project grant, program, and career development award to J.G.B.; training award to F. J.I.F. and J.S.R.; postgraduate research fellowship to J.S.R.; Infrastructure for Research Institutes Support Scheme); Australian Research Council (Future Fellowship to J.G.B.); National Institutes of Health (United States); and the Victorian State Government Operational Infrastructure Support grant, Australia.