Journal article
Catecholaminergic Polymorphic Ventricular Tachycardia in Children: Analysis of Therapeutic Strategies and Outcomes from an International Multicenter Registry
TM Roston, JM Vinocur, KR Maginot, S Mohammed, JC Salerno, SP Etheridge, M Cohen, RM Hamilton, A Pflaumer, RJ Kanter, JE Potts, MJ LaPage, KK Collins, RA Gebauer, JD Temple, AS Batra, C Erickson, M Miszczak-Knecht, P Kubuš, Y Bar-Cohen Show all
Circulation Arrhythmia and Electrophysiology | Published : 2015
Abstract
Background - Catecholaminergic polymorphic ventricular tachycardia is an uncommon, potentially lethal, ion channelopathy. Standard therapies have high failure rates and little is known about treatment in children. Newer options such as flecainide and left cardiac sympathetic denervation are not well validated. We sought to define treatment outcomes in children with catecholaminergic polymorphic ventricular tachycardia. Methods and Results - This is a Pediatric and Congenital Electrophysiology Society multicenter, retrospective cohort study of catecholaminergic polymorphic ventricular tachycardia patients diagnosed before 19 years of age. The cohort included 226 patients, including 170 proban..
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Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
This study received financial support from the National Institutes of Health (Bethesda, MD, grant no. HL108173) and the Rare Disease Foundation (Vancouver, BC).