Journal article

A mass spectrometric and ab initio study of the pathways for dehydration of simple glycine and cysteine-containing peptide [M H]( ) ions

GE Reid, RJ Simpson, RAJ O'Hair

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | ELSEVIER SCIENCE INC | Published : 1998

Abstract

The gas phase fragmentation reactions of the [M+H]+ and [M+H - H2O]+ ions of glycylglycine, glycylcysteine, N-acetylglycine, N-acetylcysteine, their corresponding methyl esters, as well as several other related model systems have been examined by electrospray ionization (ESI) tandem mass spectrometry (MSn) using triple quadrupole and quadrupole ion trap mass spectrometers. Two discrete gas phase fragmentation pathways for the loss of water from glycine-containing peptides, corresponding to retro-Koch and retro-Ritter type reactions were observed. Two pathways were also observed for the loss of water from C-terminal cysteine-containing peptides: a retro-Koch type reaction and an intramolecula..

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