Journal article

Motor and behavioral phenotype in conditional mutants with targeted ablation of cortical D1 dopamine receptor-expressing cells

Luning Jiang, Claire O'Leary, Hyun Ah Kim, Clare L Parish, Jim Massalas, John L Waddington, Michelle E Ehrlich, Guenter Schuetz, Ilse Gantois, Andrew J Lawrence, John Drago

NEUROBIOLOGY OF DISEASE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2015

Abstract

D1-dopamine receptors (Drd1a) are highly expressed in the deep layers of the cerebral cortex and the striatum. A number of human diseases such as Huntington disease and schizophrenia are known to have cortical pathology involving dopamine receptor expressing neurons. To illuminate their functional role, we exploited a Cre/Lox molecular paradigm to generate Emx-1(tox) MUT mice, a transgenic line in which cortical Drd1a-expressing pyramidal neurons were selectively ablated. Emx-1(tox) MUT mice displayed prominent forelimb dystonia, hyperkinesia, ataxia on rotarod testing, heightened anxiety-like behavior, and age-dependent abnormalities in a test of social interaction. The latter occurred in t..

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Grants

Awarded by National Health & Medical Research Council (NHMRC) of Australia


Awarded by Science Foundation Ireland principal Investigator


Funding Acknowledgements

This work was supported by project grants from the National Health & Medical Research Council (NHMRC) of Australia [509072] and [628680], the Victorian Government's Operational Infrastructure Support Program and by Science Foundation Ireland principal Investigator grant 07/IN.1/B960. JD and AJL are Fellows of the NHMRC, Australia. CLP is a Viertel Senior Medical Research Fellow, Australia.