The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET
William E Klunk, Robert A Koeppe, Julie C Price, Tammie L Benzinger, Michael D Devous, William J Jagust, Keith A Johnson, Chester A Mathis, Davneet Minhas, Michael J Pontecorvo, Christopher C Rowe, Daniel M Skovronsky, Mark A Mintun
ALZHEIMERS & DEMENTIA | WILEY | Published : 2015
Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission tomography), and now with F-18-labeled tracers, has produced remarkably consistent qualitative findings across a large number of centers, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. In some cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of course, different tracers yield different numbers. Our working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls (..View full abstract
Awarded by National Institute on Aging
This work was supported in-part by grants from the National Institute on Aging: R37 AG025516 (WEK), P01 AG025204 (WEK), P50 AG005133 (WEK), R01 AG034570 (WJ), P01 A0026276 (TB), and U19 AG032438 (TB). We would like to thank Marybeth Howlett for her organizational and administrative support.