Journal article

The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET

William E Klunk, Robert A Koeppe, Julie C Price, Tammie L Benzinger, Michael D Devous, William J Jagust, Keith A Johnson, Chester A Mathis, Davneet Minhas, Michael J Pontecorvo, Christopher C Rowe, Daniel M Skovronsky, Mark A Mintun

ALZHEIMERS & DEMENTIA | WILEY | Published : 2015


Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission tomography), and now with F-18-labeled tracers, has produced remarkably consistent qualitative findings across a large number of centers, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. In some cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of course, different tracers yield different numbers. Our working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls (..

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