Journal article
Immunological markers that predict radiation toxicity
CN Sprung, HB Forrester, S Siva, OA Martin
Cancer Letters | Published : 2015
Abstract
Radiotherapy is a major modality of cancer treatment responsible for a large proportion of cancer that is cured. Radiation exposure induces an inflammatory response which can be influenced by genetic, epigenetic, tumour, health and other factors which can lead to very different treatment outcomes between individuals. Molecules involved in the immunological response provide excellent potential biomarkers for the prediction of radiation-induced toxicity. The known molecular and cellular immunological responses in relation to radiation and the potential to improve cancer treatment are presented in this review. In particular, immunological biomarkers of radiation-induced fibrosis and pneumonitis..
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Awarded by National Institutes of Health
Funding Acknowledgements
This project was supported through the National Institutes of Health (grant 5U19AI067773-07) and the 2010 round of the priority-driven Collaborative Cancer Research Scheme (grant 1002743) funded by the Department of Health and Ageing, Australian Government with the assistance of Cancer Australia. Also, this work was supported by the Australian National Health and Medical Research Council (grant 10275598). Support was also provided by the Victorian Government's Operational Infrastructure Support Program.